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Bacterial Resistance Strategies

To survive in the presence of an antibiotic, bacterial organisms must be able to disrupt one or more of the essential steps required for the effective action of the antimicrobial agent (see Pharmacology Module, Mechanisms of Action).  


The intended modes of action of antibiotics may be counter-acted by bacterial organisms via several different means.  This may involve preventing antibiotic access into the bacterial cell or perhaps removal or even degradation of the active component of the antimicrobial agent.  No single mechanism of resistance is considered responsible for the observed resistance in a bacterial organism.   In fact, several different mechanisms may work together to confer resistance to a single antimicrobial agent.

 

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MECHANISMS OF RESISTANCE AGAINST DIFFERENT ANTIMICROBIAL CLASSES
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ANTIBIOTIC MODES OF ACTION AND BACTERIAL MECHANISMS OF RESISTANCE

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