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Chloramphenicol

 

Mode of action:

 

Inhibition of protein synthesis, Chloramphenicol irreversibly binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase. This inhibition consequently results to the prevention of amino acid transfer to growing peptide chains, ultimately leading to inhibition of protein formation.

 

Spectrum of activity:

Broad spectrum

 

Effect on bacteria:

Bacteriostatic

Examples of applications in Veterinary Medicine:

Because of its capacity to cause fatal aplastic anemia in humans, chloramphenicol is prohibited in food animals in the US and many countries.

 

May be considered for some anaerobic infections in companion animals, such as serious ocular infections, prostatitis, otitis media/interna and salmonellosis. 

 

Miscellaneous:

 

Causes bone marrow depression and may compromise antibody production if given prior to vaccination.

 

Anaphylaxis, vomiting and diarrhea have been reported in dogs and cats, the latter being more likely to be susceptible to toxicity. 

 

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