Diaminopyrimidines (Trimethoprim)
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Mode of action:
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Inhibition of other metabolic processes. Trimethoprim interferes with folic acid pathway by binding the enzyme dihydrofolate reductase.
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Example: |
Trimethoprim, Aditoprim, Baquiloprim, Ormetoprim
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Source: |
Synthetic |
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Spectrum of activity: |
Broad spectrum; affects Gram-positive and many Gram-negative bacteria
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Effect on bacteria: |
Bacteriostatic
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Add-ons: |
Act synergistically (and becomes bactericidal) in combination with sulfonamides |
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