Skip to content. | Skip to navigation

There is a newer version of this site available at

Personal tools



Mode of action:


Inhibition of nucleic acid synthesis.  Fluoroquinolones have been shown to bind to the DNA gyrase-DNA complex and interrupt a process that leads to the negative supercoiling of bacterial DNA. This disruption leads to defects in the necessary supercoiling, and render the bacteria unable to multiply and survive.



Enrofloxacin, ciprofloxacin, Danofloxacin, Difloxacin, Ibafloxacin, Marbofloxacin, Pradofloxacin, Orbifloxacin




Spectrum of activity:

Broad spectrum – 3rd generation fluoroquinolones

Narrow spectrum – other fluoroquinolones


Effect on bacteria:



Examples of applications in Veterinary Medicine:

  • Ruminants – acute respiratory disease, infections with E. coli, Salmonella, Mycoplasma, mastitis, metritis, conjunctivitis
  • Swine – treatment of infections caused by Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Escherichia coli, and Pasteurella multocida.Should never be administered in feeds because residues can contaminate the environment; prohibited for use in pigs in some countries.
  • Horses – for infections with bacteria resistant to the first drug of choice; not recommended in young growing horses (may cause cartilage erosion)
  • Dogs and Cats – prostatitis, mastitis, rhinitis, pyoderma, otitis, wound infections, peritonitis, osteomyelitis, and soft tissue infections; not recommended for use in animals <8 months of age (or <18 months of age for large breed of dogs to avoid arthropathoc effects.




Available formulations and/or approved use in different animal species vary widely between countries; sometimes used extra-labelly, but may be prohibited in some countries.





Document Actions