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Lincosamides

 

Mode of action:

 

Inhibition of protein synthesis.  Lincosamides bind to the 50S ribosomal subunit and inhibit peptidyl transferases. 

Example:

Lincomycin, Clindamycin and Pirlimycin

 

Source:

Streptomyces lincolnensis subsp. lincolnensis

Spectrum of activity:

Moderate-spectrum; they are primarily active against Gram positive bacteria, most anaerobic bacteria and some mycoplasma.

 

Effect on bacteria:

Can be bactericidal or bacteriostatic, depending on the drug concentration, bacterial species and concentration of bacteria. 

 

Examples of applications in Veterinary Medicine:

q    General: clindamycin has an excellent activity against anaerobes;

q    Swine: lincomycin is used extensively in the prevention and treatment of dysentery and sometimes in mycoplasma infections.

q    Cattle: used as intramammary infusion in mastitis (pilrimycin);

q    Horses: should not be used in horses;

q    Dogs and cats: for infections with Gram positive cocci and anaerobes

q    Poultry: for the control of mycoplasmosis (usually in combination with spectinomycin) and necrotic enteritis.

 

Miscellaneous:

 

Should not be used in horses.

 

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