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Sulfonamides

 

Mode of action:

 

Inhibition of other metabolic processes.  Sulfonamides interfere with folic acid synthesis by preventing addition of para-aminobenzoic acid (PABA) into the folic acid molecule through competing for the enzyme dihydropteroate synthetase.

Example:

Sulfadiazine, sulfamethoxazole, sulfadoxine

 

Source:

Synthetic

Spectrum of activity:

Broad-spectrum; affects Gram-positive and many Gram-negative bacteria, toxoplasma and protozoal agents

 

Effect on bacteria:

Bacteriostatic

 

Add-ons:

Act synergistically (and becomes bactericidal) in combination with diaminopyrimidines (trimethoprim)

 

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